First a little bit of background about me: I took accutane when I was 14-15, it left me with serious ED as well as caused my hair to shed profusely. Unfortunately when I was around 17-18 I was continuing to lose my hair so I thought I was experiencing male pattern baldness, as a result I decided to go on propecia as well. Predictably this messed my body up even more. Long story short, I have been suffering from the combined side effects of both accutane and propecia for the past 14 years of my life. I am 29 now. Up until about a month or so ago I was suffering from combined accutane and propecia side effects, but since discovering this new protocol I have been experiencing benefits and recovery like nothing I have ever experienced before. Trust me, I have had this problem for the past 14 years of my life, so I have tried just about everything to cure myself, and nothing has really worked for me until I figured out this protocol. The following is a repost of a post that I made on solvepfs.com, so it is mainly referring to PFS throughout the post. However like I said, I suffer from both accutane and propecia side effects, so Im confident that this protocol will work for accutane side effects sufferers as well. Due to a recent chain of events and experimentation with a few things, I have stumbled across a new protocol that might be the cure for PFS. (as well as accutane side effects) Basically what my protocol involves is the strategic use of zinc, time, and the body's own homeostasis mechanisms to recover. What caused me to discover this new protocol was that I was recently experimenting with large doses of creatine (1 heaping tablespoon per day which is 20 grams of creatine) and it gave me negative effects within only 15-20 minutes of taking it. (general feeling of being disconnected, slight discomfort, shrinkage and no morning wood) After experimenting with it for a few days and seeing that it was completely counter-productive, it occurred to me that maybe I could use zinc (a known 5AR inhibitor) to possibly reverse the temporary side effects brought on by creatine. (a known 5AR/DHT increaser) So, I took 200 mg of zinc and literally within 15-20 minutes (a surprisingly fast amount of time), all the side effects of creatine had subsided and my entire body was filled with a very warm, connected feeling. Additionally the shrinkage caused by creatine reversed and I woke up with good morning wood the next day. It was this event that caused me to realize the potential utility of zinc. Not just as a mineral supplement, but rather as a means to reliably influence the hormones. So after this discovery, through a few weeks of trial and error, as well as lots of theoretical conjecture, I came up with this new protocol. First of all though, I want to run through a few theories that VAPP (variability and ping protocol) is based on: In my opinion there are actually two types of PFS: PFS type 1: 5AR/DHT levels are impaired but androgen receptors are still somewhat functional. (They are still abnormal though) People with PFS type 1 respond best to things like creatine, sorghum, weightlifting, etc. Basically anything that boosts 5AR/DHT. PFS type 2: 5AR/DHT levels are too high relative to the sensitivity levels of the androgen receptors. People with PFS type 2 respond best to things that lower 5AR/DHT levels, such as zinc, marijuana or even things like saw palmetto and microdoses of propecia. (wouldnt recommend the last one though) On this topic, whether you are PFS type 1 or 2 is not fixed necessarily. By that I mean that if you are PFS type 2 but overuse zinc, marijuana, saw palmetto etc then you can lower your 5AR/DHT levels too much which can cause a crash and make you become PFS type 1. Likewise, if you are PFS type 1 but overuse creatine, sorghum, tribulus etc then it will make you crash and you will become PFS type 2. So with me, I strongly believe that I have PFS type 2. This is because I respond poorly to creatine (and really anything else that boosts 5AR/DHT) but respond fairly well to zinc. Also what I deduced from my experience is that when it comes to PFS type 2, it is true that your 5AR/DHT levels are too high. What is also true is that for your androgen receptors, they have a set range of DHT levels that they are sensitive to. If your DHT levels are over or below this range then you will not be able to utilize DHT properly. For people with PFS type 2, they simply have too much DHT relative to the sensitivity range for their androgen receptors, thus their bodies cant properly respond to the DHT. So for me, I had initially boosted my DHT levels too high by using creatine and it made my DHT levels out of the sensitivity range of my androgen receptors. Thus giving me side effects. However by taking zinc, it had a speedy effect in reducing my DHT levels to within the sensitivity range of my androgen receptors. This in term reversed the side effects brought on by creatine, as well as giving me very strong morning wood the next day. I want to add that from my subsequent experiments with zinc I have noticed that if I take too much then my morning wood also goes away. In my opinion this is further evidence for the theory that there is an optimal DHT range for the androgen receptors. It is not simply the case that those with PFS have completely inactive/desensitized androgen receptors. At this point, through a lot of experimentation with zinc and keeping the above point in mind, I begin toying with the idea of using zinc to properly modulate my 5AR/DHT levels in sync with my body's own natural homeostatic cycles in order to better align my DHT levels with the sensitivity range of my androgen receptors. So in order to achieve this, I began supplementing with 100 mg of zinc every other day. I would do this until my morning wood would begin to get weak or even go away. At this point I would stop taking zinc for 3-5 days and then after 3-5 days was up then I would start taking zinc again. The reason for taking zinc every other day was to hopefully keep my DHT levels within a certain range, and not have them go too far up or down. However by utilizing this alternate day zinc protocol it actually lead me to discover another interesting phenomena which I will explain more in depth in the paragraph below: I'll start out my explanation with an example. So if you take zinc, its going to temporarily depress your 5AR/DHT levels, however as the effect of the zinc begins to wear off, your body will naturally begin to regenerate its 5AR/DHT in order to restore homeostasis. Likewise, if you take creatine its going to temporarily spike your 5AR/DHT levels but afterwards your body will naturally bring your 5AR/DHT levels back down. That being said, it is through the process of the body attempting to return to its baselines that you can "hack" the body and change the baselines. For lack of a better term, I will refer to this mechanism as "variability". It is through consistently varying the levels of certain hormones and then allowing them to briefly recover that you can change your baselines. That being said though, when attempting to utilize variability its very important that you allow the body to attempt to return to its baselines through its own natural mechanisms. If you try to artificially induce variability by using multiple contradicting supplements to manipulate hormone levels then you actually reduce the effectiveness of variability. Thus you should not mix and match your supplements. IE use zinc and creatine at the same time. The same goes for concurrently taking zinc and lifting weights. I'll elaborate more on this later though. The important thing is to just manually adjust the levels of a certain hormone and then to let the body handle the rest. (IE Only take a given supplement every other day.) The mistake that we have been making up until now is that we were so eager to recover that we were taking supplements on a daily basis because we thought it would be more beneficial when actually it appears that it is more beneficial to take supplements every other day. Anyways, it is through variability that I feel like you can actually set an optimal baseline for your hormones.