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Cabergoline discussion thread

Discussion in 'Post-Finasteride Syndrome & Accutane Sufferers' started by Took_accutane, Jan 26, 2013.

  1. Took_accutane

    Took_accutane Member

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    I wanted to start a thread about cabergoline since it seem to be one of the few things that actually seems to work. The other appears to be pramipexole but more people seem to experience sedation or sleepiness with this, though maybe if they used it for a longer period it might subside. But caber seems to be one that people post good results with. The big concern is about its links with heart disease. In the amounts that would be used for our purposes, which would be similar or less to the amount used for a prolactinoma patient, there are quite a number of studies that say long term use of it isn't associated with heart disease. I realise there are others out there which contradict these.

    http://www.ncbi.nlm.nih.gov/pubmed/18594989
    http://www.ncbi.nlm.nih.gov/pubmed/19959151
    http://www.eje-online.org/content/159/4/R11.abstract
    http://onlinelibrary.wiley.com/doi/10.1111/j.1742-1241.2008.01779.x/abstract
    If you have weak/no orgasms you could want to bring this to your doctor as a starting point. I will be taking it to my urologist in a few weeks. Not expecting it to get anywhere but worth a try:

    http://www.medpagetoday.com/MeetingCoverage/AUA/32903
     
    Last edited: Jan 26, 2013
  2. FormerMember1234

    FormerMember1234 Banned

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    unfortunately there are many other studies which show the fibrotic side effects of it.I like the drug very much but i would only take it for some months in order to attempt to achieve some permanent improvement if possible.

    What i haven't tried and researched enough till now is the possibility of taking simultaneously a drug with 5ht2b antagonistic properties.In theory this could block the agonistic properties of cabergoline at the 5ht2b receptors and it would make it safe for longterm use.The 5ht2b antagonist should have a long half life though like cabergoline.
     
    Last edited: Jan 26, 2013
  3. Took_accutane

    Took_accutane Member

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    Some brief discussion on 5ht2b antagonists:

    http://www.bluelight.ru/vb/threads/...lve-pulmonary-damage-in-combination-with-amps

    Personally I think this may be the closest we will come to a "cure" at present: use of cabergoline simultaneously with some kind of 5ht2b-antagonist to prevent heart problems. Until the Fin studies can give us other leads or possibility.

    I strongly encourage Accutaners to contribute to the Fin research fund.
     
    Last edited: Jan 26, 2013
  4. malden

    malden New Member

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    Hello!

    bit off topic, but its relative
    ropinirole is the best-savest-dosing candidate I think, for me caber was nice but only when im dosing higher than the recommended `safe` dose for prolactin.

    hydergine same story.. :angry:

    ropinole alsow have interest in the post ssri erectile dysfunction forums, seems like it helps them very good.
     
  5. Took_accutane

    Took_accutane Member

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    I read that ropinirole causes more side effects than pramipexole. Such as tiredness, need for sleep, etc. I would like to try both, ideally. This is only what I have read - often reality is different to what you read. Such as with Accutane medication, no permanent erectile problem was mentioned in the leaflet. You only find out aftewards, LOL. Like with finasteride.. they had to add it in later, once people began complaining.
     
    Last edited: Jan 26, 2013
  6. malden

    malden New Member

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    there a lot of conflicting data about this indeed, for me i had big hope for pramipexole. but i get verry sick on it, and dont feel good. )i have taken low doses and titrated ect.

    gaber dont give much sides, a bit orhtostatic intolerance and short term memory problems were very noticeable. over all it was oke.

    prami is a good try, D agonist are a personal thing a think

    exited wat is does for you! and have a good weekend over the bwt
     
  7. JanSz

    JanSz Well-Known Member

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    If the goal is to reduce prolactin,
    similar results may be obtained using (specifically) Cycloset.

    Cysloset is good at lowering blood glucose.

    Thinking of one stone and two birds.




    ========================================================================
    Cabergoline
    Cabergoline is a long-acting dopamine-agonist drug that suppresses prolactin secretion and restores gonadal function in women with hyperprolactinemic amenorrhea.
    http://www.nejm.org/doi/full/10.1056/NEJM199410063311403

    Cabergoline (brand names Dostinex and Cabaser), an ergot derivative, is a potent dopamine receptor agonist on D2 receptors. In vitro, rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph (prolactin) cells.[1] It is frequently used as a first-line agent in the management of prolactinomas due to higher affinity for D2 receptor sites, less severe side effects, and more convenient dosing schedule than the older bromocriptine.
    http://en.wikipedia.org/wiki/Cabergoline
    ---------------------------------------
    Bromocriptine
    (INN; trade names Parlodel, Cycloset), an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.
    http://en.wikipedia.org/wiki/Bromocriptine
    ---------------------------------------
     
  8. Took_accutane

    Took_accutane Member

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    Re: Pubmed article from 2010 on drugs in development for ED

    http://www.medpagetoday.com/MeetingCoverage/AUA/32903

    Drug Restores Normal Orgasm in Men
    I have seen a report from a patient on here using caber. I presume was prescribed by Dr J. I haven't looked for other reports on here yet. The date of the article and study is from 2012. It is recent. Maybe they are just starting to explore the use of DAs for sexual dysfunction in greater detail. Probably others will be able to find older studies. There is a lot of "talk" on other forums of different kinds about use of DAs for sexual function. Especially caber. Just trying searching around.
     
  9. DaveK22

    DaveK22 Member

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    Re: Pubmed article from 2010 on drugs in development for ED

    I'll be starting cabergoline this week at .25mg E3.5D. I'll report my experience as we go. Hoping for increased libido & orgasm strength. We'll see.

    Post 'tane:
    Libido: 2/10
    Orgasm: 5/10

    TRT (2 pumps/40.5mg) & Clomid (12.5mg ED):
    Libido: 3/10
    Orgasm: 5/10

    TRT (2 pumps/40.5mg) & Clomid (12.5mg ED) + Cialis for Daily use (5 mg ED):
    Libido: 4/10
    Orgasm: 5/10

    TRT (2 pumps/40.5mg) & Clomid (12.5mg ED) + Cabergoline (.25mg E3.5D):
    Coming soon...pun intended ;)
     
  10. DaveK22

    DaveK22 Member

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    Re: Pubmed article from 2010 on drugs in development for ED

    Quick update...

    Been on Caber for 2.5 months now. Dose was .25mg E3.5D for 2 months. Then I tried .5mg E3.5D for a few weeks. Unfortunately, I have felt no effect at all. Libido & orgasm strength has no change, nothing else noticeable either. After my 3 month supply is used up, I don't see any value in continuing. Not sure if I want to experiment with any higher doses either at this point. Maybe others will have better successs but just wanted to report my experience.
     
  11. Took_accutane

    Took_accutane Member

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    Re: Pubmed article from 2010 on drugs in development for ED

    Thanks for sharing your experience. I noted that one forum member, Pab, also found no improvement using Cabergoline. He titrated the dose steadily upwards but gained no benefits. Subsequently he used pramipexole and found improvements using this. You may want to look into using pramipexole or ropinirole.
     
  12. foreveryoung

    foreveryoung New Member

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    Re: Pubmed article from 2010 on drugs in development for ED

    I have used all four and for me it seems like the best results were on both hydergine and cabergoline at the same time

    I had no luck at all with ropinirole, in fact some terribly bad timing for ED happened to me when I was on ropinirole

    pramipexole I am still uncertain about, it seemed to help some of the time, and other times not at all, but the mental side effects of it made me feel depressed and "med-ed"

    still unsure of all of these as there are so many possible variables that can occur around the situation when you might be taking one or another
     
  13. lateral

    lateral New Member

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    Any update on the vascular side effects of caber?
    Thanks in advance.
     
  14. BadassBlues

    BadassBlues Super Moderator Staff Member Super Moderator

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    This thread has been inactive for a long time Lateral. What kind of vascular side effects are you referring to? If you are referencing the effects on heart valves and lungs the data was accumulated based on long term usage.

    For the purposes of sexual enhancement, caber should be cycled. If the dosage of 2.5 mg. E3D isn't working, you should discontinue the drug as it will not net better results at higher, or more frequent doses. DA's in general are only effective in bursts, if at all. Any long term usage results in a down regulation of the receptor sensitivity.

    Keep in mind, cabergoline is prescribed for those with prolactinomas. The data that has been examined is based on that subset. There is no data for those who are using this drug intermittently for sexual enhancement.
     
  15. lateral

    lateral New Member

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    I missed your reply....
    I have a Prolactinoma and resultant osteoporosis also mild aschemic heart disease.
    Hence my interest in vascular effects of cab.
    Had high PL for years, just went undiagnosed.
    Thought my disinterest in the opposite sex was just mental, peculiar to me.
    Thanks....
     

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