Very sorry to hear of Dr. Johns passing. Also very worried about finding proper health care once again. Before Dr. John I had severe prostate issues. I had low normal T levels and high normal E2. My prostate was larger than normal. Had hard spots. I had to try to pass urine constantly and never felt empty. I was able to get T therapy but never able to get my E2 lowered by anyone local. Increasing T alone did nothing for my problem. I had laser surgery back in 2007. Horrible experience. Peed blood and clots afterward. It helped short term for bathroom visits. Then the same problem returned. Then I found Dr. John. With the proper ratio of T and E2 for myself. Which is different from others I slowly returned to normal and still am to this day. Prostate is small. No hard spots. Urination is normal and no struggle to get started or empty. Reading this thread now has me very worried. I have not posted in years. Had no problem for years. That may change once again. Sucks! BTW I am now 60.