So, I am now up to 2.5 grains of Armour. For adrenal support, I take Isocort (3-2-1), as well as Advair in the morning; I also take licorrice root in the a.m., and Fo-ti twice a day. The good news is that my morning basal temp is 97.5 (up from 95.7), and I am not noticing any bad side effects. However, I cant say that I feel that much better. I felt great the first three days of Armour, at 1 grain (I was taking 50 mcg of Synthroid, previously). Here is the data regarding my adrenals, prior to initiating thyroid therapy: Blood plasma cortisol 19.3, which I understand is borderline, even though towards the high side of the "normal range." (The Advair that I was taken may have skewed that.) Morning saliva cortisol was 5 (range 13-24). Extremely depressed. Midnight is extremely elevated at 8 (range 1-4), the highest of the day for me. Circadian rhythm is wacked. I have a delayed sleep phase syndrome and tend to sleep best from 4 a.m. to noon, if left to my vices. ACTH is 47 (at the very high end of the range). DHEA was normal according to saliva, and low normal according to blood plasma. I would imagine that I am adequately adrenally supported, since I am not crashing. Then again, it seems that I would be feeling better, at least the first several days after I increase another 1/2 grain. I am also hypogonadal (secondary -- pituitary issue). My doc was hopeful that the thyroid treatment would iron out the testosterone issue. I would imagine that this could be part of the problem. But still, I am confounded that I am not feeling WAY better. The doc seemed so sure, and those first 3 days were like a honeymoon -- no brain fog, and I had my short-term memory back. Any ideas? Incidentally, I did just suffer a death in the family, so I have been under a lot of stress. Thanks a million for any help.