Hello everyone! It's been a while again. I have some questions that I'm hoping you fine, knowledgeable gentlemen could answer. It's about my sister: as some of you may remember, she has a background in body fitness which lead to a terrible bout of overtraining almost 2 years ago. Her body went ballistic on her; sky high cortisol, thyroid problems etc, and her psyche crashed in the wake of these endocrine problems. Good thing we managed to save her with the help of Hardasnails, her great therapist and a bunch of supplements. She was put on armour thyroid by her endocrinologist, and she's been on it and later a similar medication, "Thyroid" for a total of 1.5 years now. For the first year it all worked well and she made a tremendous recovery, even though she still had problems keeping the weight off. But for the last 6 months or so, things have been going downhill alarmingly fast. Maybe the Thyroid she's taking isn't on par with the old armour (which hasn't been available), but there must be more to it than that. She's been suffering from the following symptoms (it's as if her medication stopped working altogether): - Massive water retention. - Frequent infections, poor immune system. - Muscle weakness, loss of strength. Hardly enough strength and energy to exercise. Sometimes difficult to even walk. - Body temperature swings, from extreme cold to extreme heat. - Heart palpitations. - Weight gain, cellulite. - Lower back stiffness and pain (typical adrenal fatigue symptom?) - Pain in the soles of her feet. - Decreased quality of sleep, waking up in the early A.M. - Hard to get out of bed in the morning, general tiredness. Feels better towards the evening. - Easily out of breath, "air hunger". - Paleness. No longer tans like she used to. - Exercise causes headaches, sometimes even migraines. - Poor stress tolerance. - Amplified PMS-symptoms. - Decreased tolerance of temperature extremes. - Brain fog, sometimes difficult to focus gaze. Trouble concentrating. - Clumsiness, dropping things, dizziness. - Appetite swings (either nausea & no appetite or hard to stop eating). She is currently on 4 grains of Thyroid, and her latest thyroid labs, taken last december, are: Free T4 - 17-18 (11-21) Free T3 - 8.7 (4.0 - 6.0) TSH - immeasurably low (goes without saying) With those numbers it's clear to me that the medication stopped working and that the thyroid hormones aren't getting to her cells (when you consider all of her symptoms). Sadly her endocrinologist seems to have "stopped working" as well; his answer was along the lines of "these symptoms represent your body's personal characteristic and there's nothing I can do about them". She also ordered an adrenal saliva test kit recently and will do it soon. Her diet is relatively low carb & very low grain. Sources of fat include coconut oil, olive oil, dark cocoa, butter, eggs etc. Carbs come from fruit, berries and vegetables mainly. She also gets enough protein from different sources. How do we get her up and running again? She is nearly dysfunctional in her present state so something has to be done. Any help would be most welcome!