I'm on every 3rd day sub-q T-shots (always at 7am) and have found that I start feeling "T" rise (and estrogen to go with it) about 36 hours after my "T" shot.....and have found that if I take my 1/4mg of anastrozole the evening of the day after my T-shot....that its working right when I need it. I actually figured this out after reading this thread.....tried it the morning after my T-shot....too soon....the AI was running out 48 hours later when I still needed it. Tried taking my AI the next day at lunch time....better but still a bit too early in the cycle..... Then tried taking it about 39 hours after my T-shot (10pm next evening) BINGO! the result was really good! Now I know that if I take my AI anytime between 7pm and 10pm the next night after my T-shot....its working right when I need it to! This has been a great thread and got me to thinking about proper AI timing....no thanks to my doctor......he just said..."take a 1mg tablet twice a week" ....which was....(A) Way too damn much!!! and (B) gave me no particular times of the week to take it........ I will also say that the "advice only consults" with Dr Crisler have been invaluable in figuring this all out since my doctor is clueless (and possibly got his medical license mail order out of Tijuana or something)........oh well....at least he writes the prescription!