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PT-141 (Bremelanotide) experience

Discussion in 'Male Health & HRT' started by TopGeek, Jul 10, 2011.

  1. TopGeek

    TopGeek Active Member

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    As promised, this is an account of my first experience with this peptide. I won't go into the details of the origin of this product as it is widely described on various websites. However, it is important to know that it is a derivative of the well publicised sun tan peptide Melanotan. There is a US patent on it. However, custom peptide laboratories can easily manufacture the product against its chemical formula. Consequently, it is available from labs all over the world, most of which are very coy about their identity.
    Prior to buying my first vial, I did extensive research on various laboratories and eventually found one in Europe that has hundreds of favourable reviews from users. There's no way to know how authentic those reviews may be but, on the basis of statistical chance, I decided to go ahead with the online purchase.
    The vial arrived on Friday, with no paperwork and no label on the vial - just a coloured seal. I e-mailed the supplier for reassurance and received a very articulate response with a reasonable explanation of the reasons for that procedure.
    I decided that I was prepared to take the risk so I continued with the process of diluting the dried crystals in the vial with sterile water and then filling and freezing (-19deg C) nine insulin syringes, leaving the one that I injected at 8pm last night.
    Within 30minutes, I was aware of a warm facial glow but could see no flushing in the mirror. That feeling went away within 10 minutes and I had no further side effects before bedtime around midnight.
    At 3.30am, I awoke with a raging erection so I got up and walked around for about 30 minutes and the erection gradually subsided. I took my blood pressure and was disturbed to find that it was 155/90. I went back to bed and had a somewhat disturbed few hours, being aware of frequent erections. I eventually woke up at 8am with a strong erection but decided to try to sleep on as I was feeling exhausted.
    I again woke at 9am with no erection and my wife and I did a bit of smooching to see if it would come back but without success. That was the end of the matter. I again took my BP and it was 134/80.
    So, my first experience with PT-141 has been a 'Wow!' followed by disappointment.
    There are another nine shots in the freezer, so I will have to try it again but I don't have great expectations. The logical first step is that the injection should take place at bedtime to allow for the window of opportunity to occur in the waking hours of the morning.
     
    Last edited: Jul 10, 2011
  2. PPC

    PPC New Member

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    Thanks for sharing.
     
  3. AndroGeorge

    AndroGeorge New Member

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    Great description and thanks for sharing.

    What is your usual Blood Pressure?

    Do you have a bio with more info on your ED workup?
    This would help others who might have similar conditions...

    Thanks.

    AG
     
  4. TopGeek

    TopGeek Active Member

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    My BP has been regularly 130/80 for years but has risen to 142/85 in the last few weeks. The only change in medication that I could think of is that I dropped fenofibrate and started 200mg Niacin per day.

    My ED history has been covered in my previous posts and my blood tests are in my profile. Briefly - 71 years old now, started Viagra in 1999, Cialis in 2000, developed eye probs in 2007 which were attributed to the Cialis. Without a PDE5 inhibitor, found that I had total ED. Tried Androgel which worked fine but I did not like the testicular atrophy it caused. The rest is here:

    http://www.allthingsmale.com/forum/...hy-even-mention-PDE5-inhibitors-in-this-forum
     
  5. cumkwakka

    cumkwakka Active Member

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    if androgel worked and you're worried about testicular atrophy you could try clomid along with your androgel, i mean if it works for ED then try some clomid, you may be one of the more fortunate ones who respond good to clomid and perhaps reap extra sexual benefits
     
  6. TopGeek

    TopGeek Active Member

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    The ED specialist that I saw last year told me he would not prescribe Clomid because it also has a high risk of eye problems. It's also supposed to not work for men over about 45 -50 years of age. On the other hand, HCG could work but the combined private cost of Androgel and HCG would be very high, especially compared to PT-141.
     
  7. JanSz

    JanSz Active Member

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    Yes, I would stay away from Clomid and PDE5's due to already established vision problems..

    But you just reminded me that you have a low BAT.
    Raising it may help with erections on its own, but possibly combination BAT + (PT-141) and control of E2 may be better ticket to a happy wife.

    I do not remember your DHT levels.
    Usually only few people need (expensive) Androgel because of their low DHT.
    Most can happily get by using Testosterone enanthate, cypionae or Sustanon-250.
    Injectable testosterone and HCG are highly inexpensive when comparing to coast of Androgel.

    In the past you were leery about injections.
    But you are not a virgin now, after little experience with PT-141
    Just use 31Ga 5/16" long needles and you will not even know that you are injecting.
    First two months inject around nave 1"-3" off the navel.
    ...........
     
    Last edited: Jul 10, 2011
  8. TopGeek

    TopGeek Active Member

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    I must be suffering brain fog today JanSz.

    What is BAT?
     
  9. TopGeek

    TopGeek Active Member

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    The one thing I guess the bremelanotide erection proves is that I don't have a blood-flow problem. It was also an erection the like of which I have not experienced for many years. Consequently, I think I could be quite happy with that, so long as I can get the timing right. Spontaneity is out of the window but ...
    Presumably the 'window of opportunity' varies from one person to another but to me it looks like 12 hours. That's disappointing because the rave notices about the product suggested that it could be effective for as long as two days.
     
    Last edited: Jul 10, 2011
  10. JanSz

    JanSz Active Member

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    BAT-BioAvailableTestosterone


    .........
     
  11. JanSz

    JanSz Active Member

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    That was one of the kind erections. Follow ups may not be as strong but still usable.
    Just tell your girl to not waste time when the time comes.

    Good E2 levels are highly important in this context.

    ...
     
  12. TopGeek

    TopGeek Active Member

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    I'm still taking 50mg DHEA per day and 0.25mg Arimidex EOD.
     
  13. Sharpman28

    Sharpman28 New Member

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    Topgeek, thanks for sharing your experience.

    I am wondering, why don't you try HCG monotherapy
    or testosterone with HCG? HCG would help the testicular
    shrinking and does not give eye problems as far as I know.

    Sharpman
     
  14. TopGeek

    TopGeek Active Member

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    Of course! Unfortunately, I do have rather high shbg so I have to either raise T or lower shbg in order to raise BAT. As we all know, it's not easy to lower shbg and supplementing T has undesirable side-effects.
     
  15. JanSz

    JanSz Active Member

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    I like good levels of BAT.

    You have high SHBG & CBG (Transcortin).
    Possibly some other binding proteins are out of their normal range.

    If you would arrange for high dose of testosterone your SHBG (and possibly Transcortin) would get down.
    We had couple guys doing it with this (predictable) results.
    One of those guys is Bryce720 who on top of other problems have hemachromatosis due to genetic problems.

    On one of the dr Gordon's presentations I noted that he is not a shy at all in raising testosterone when facing patient with high SHBG.
    Dr Gordon is on dr John's list of favorite doctors.

    Dr Vermulen's chart is handy to monitor theraphy.
    You normally want to get your FreeTestosterone into
    FreeT(250-300)
    range
    In this case, to put more pressure on SHBG, FreeT~400 may do better job.
    Dr Gordon went out up to FreeT~475 on the patient discussed on presentation I observed.
    ==============================================
    I imagine procedure for you:
    Testosterone Cypionate 200mg/mL

    T-shot=25units/day=50mg/day=350mg/week
    HCG-shot=400iu/EOD

    Mandatory, frequent monitoring of at least

    Hgb (phlebotomy when >(16.5-17.5)
    SHBG (goal ~20)
    E2, sensitive (goal ~20)
    Dihydrotestosterone
    5α-Androstane-3α, 17β-Diol Glucuronide, Serum

    If you can arrange there is more interesting tests that you may consider.



    ==============================================

    [​IMG]
     
  16. TopGeek

    TopGeek Active Member

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    Well, I suppose that point is proven for me by the fact that Androgel works just fine. However, it (like all exogenous T) has serious disadvantages such as testicular atrophy and the risk to your partner through contact transfer. Of all the options I've seen so far, PT-141 seems to be the easiest way of restoring erectile function without serious side-effects - as far as we know.
     
  17. TopGeek

    TopGeek Active Member

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    HCG monotherapy does indeed sound like it would be worth trying. The only reason I've not done so is that all the European sources I've found require a prescription and my doctor is not willing to prescribe it.

    Note: That said, I have now found an east European site that is offering branded HCG at reasonable prices, with prescription. At the same time, I have seen that HCG causes LH desensitisation, which presumably means there is no going back. Oh boy! Isn't there always a sting in the tail?
     
    Last edited: Jul 12, 2011
  18. 956Vette

    956Vette New Member

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    PT-141 is great for recreational intermittent use. Stimulating the receptors in the brain should not have affected your blood pressure as much as it did. 1mg for the first experiment yielded exactly what I would have predicted. Better off to first test your sensitivity and experience with 250-500mcg PT-141 - 1mg is a seasoned user dosage.
    Good luck with the next dosage/timing!
     
  19. JanSz

    JanSz Active Member

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    Disregarding effects on skin color.
    Speaking only about erection improvements.

    It appears that the very first shot of PT-141 works real well.
    Problem is with following shots.
    They do not work that well, if at all.

    There is probably some period of time after which, one would react as if it was again a first PT141 shot.

    How to figure it out shortest time to the next shot that would still provide substantial erection improvements?

    Per your comments above it looks like 250-500mcg PT-141 shots are more appropriate.

    Any known differences if instead Melanotan II is used??

    In time when PT141 works, what is actually improved other then erection during first intercourse.

    Length of first intercourse??
    Refractory period to the next session??
    Number of sessions per evening?
    Anything else.

    956Vette, any pointers you are able to provide, that much it would help others in having fun, or help TopGeek be able to participate in sexual activity.
    Due to side effects (vision0 TopGeek is not allowed to use any PDE-5's.



    .
     
    Last edited: Jul 12, 2011
  20. TopGeek

    TopGeek Active Member

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    Thanks for that info. The instructions on the site that I used did not talk about alternatve doseage and only suggested dividing the vial into ten 1ml syringes. That first erection was indeed a bit too strong - not uncomfortable but it could have been less and still satisfactory. I'll try a smaller dose next time. I did wonder if 0.5mg followed by another 0.5mg four hours later would increase the window of opportunity.
     

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