I started , and now they are lost, a few postings on my experiment with LDN (low dose Naltrexone) as a replacement for Embrel and Methotrexate for my RA (Rheumatoid Arthritis). I continue on daily T Cyp at 10 units/ 70 a week, last TT was 740. E2 was 24, so no AI. Here are a few of my notes, from Yahoo LDN/RA group: Started D,L-phenylalanine, ,also take a few amino acids before I head to the gym in AM.The pain in my L hand, like RA pains in general is now gone, and replaced with another area, I have increased my Green Pastures fermented Cod Liver oil, I think that has helped. My CRP was slightly elevated, but still just barely, for someone with RA. I increased my dose to 2.4 mg last night, wanted to creep up on 3.0 mg, a few days at a dose. I do take 88mcg of synthroid, and was taking 5mcg of T4 twice a day, but noticed a slight increase in Tachycardia, so shifted my T4 to awakening, and not bedtime. I guess thyroid meds will need to be adjusted. I awoke this AM with a temp of 98.1. I was concerned even more because my Temps kept rising each morning, until a few days ago it was 98.9. Took 5mg of prednisone twice a day and my temp is already back into the normal AM range. Pain is down 80%, returned to the gym this AM. I ordered 2.5 mg tabs of Prednisone last Rx and I hope to shift down to 2.5mg twice a day. Until the LDN has kicked in. I am currently at 3mg dosing each night of LDN. Sleep is mostly better, I did discover too much sugar in PM will still effect my sleep, had ice cream at 6pm, and awoke more than usual.RA pain in various joints continues, so I continue with Prednisone dosing. I have moved between 5 to 10 mg /day, using 2.5mg tabs. I have received a few notes asking about taking the Prednisone and LDN concurrently, my rationale for spacing the Prednisone dosing out is the short half half. At 60 minutes, and completely gone in 3 to 4 hours, if you are using Prednisone to reduce inflammation, and thus pain, then taking multiple doses a day will benefit you. Sorry for the lengthy catch up posting, but, I am writing a twice a week post at Yahoo, so, this is a synopsis.I have now been on LDN about a month. Starting slowly with an introductory dosage pattern has helped with side effects, I have not suffered much in sleep. I do have "better" not bizarre or scary dreams. With low doses of Prednisone, I have controlled the RA pains that I get many days. The current thought in the LDN community is that 10mg or less is not Immune supressive. As to Pro Libido effects, slight improvement, and it does seem to help with night time and awakening erections.