Discussion in 'Post-Finasteride Syndrome & Accutane Sufferers' started by Bman5, Sep 30, 2016.
I have been weary of using Finasteride, but after reading this actual study it appears that my concerns may be unfounded. According to this research, 3 groups of men were compared: men who never took the drug, men who took the drug and had no complaints, and men who took the drug and had severe complaints. However, extensive examinations of various hormone levels and ratios, body fat comparisons, strength comparisons, and memory/recall tests compariosns showed that there were no significant differences across the 3 groups. The post-Finasteride recruits did not differ from the general population in any of these measures. They did show signs of depression and low sexual desire, but as the researchers stated, this was not surprising since that is why they self-selected themselves for the study. The researchers went on to state that there was no link between Finasteride and the depressive symptoms of the patents.
So, what am I missing here? To be clear, I am not a fan of big pharmaceuticals, and I am not ruling out the possibility that something is still not right with this drug. However, this study that does not seem to lend much credence to the claims. Does anyone have some thoughts on this, or links to controlled studies that highlighted a potential danger? I am strongly considering using this medication for thinning hair, but do not want to take any unwarranted risks. Thanks for any information!
I used finasteride for 15 years. Had excellent sexual fxn for 13 of those years. Then one year had a failure in the bedroom. It led to performance anxiety and repeated failures. I now have such severe issues that I must use cialis or viagra before sex which has subsequently led to depression. On one hand I could attribute this all to finasteride use. I did discontinue the med a year ago just to be safe. I however believe it likely had nothing to do with the med as the symptoms started after 13 years of normal functioning and I was able to perform just fine with my ex gf but had complete inability with anyone new. So what's my point? I think a lot of men attribute their sexual dysfunction to finasteride when they are really either experiencing psychological or vascular ED. Check out these studies. Just shows how powerful the power of suggestion is (nocebo effect)
Thank you for including the studies. This is useful information, and it points to an obvious point -- the idea of a "post finasteride syndrome" may actually be nonsense, and similar to the breast implant scare that occurred many years ago and was proved to be false. To be clear, I do think that there are many men that are suffering from something, but it seems increasingly likely that finasteride is not the culprit. (No, I do not work for a drug company).
The main study that the PFS foundation funded showed no clear link, or differences across other populations in key dimensions that included body fat measures, extensive hormone panel comparisons, cognitive tests (3), and strength tests. This is a bit shocking, despite the nonsensical spin that they attempted to put on the results. And, it is interesting to point out that the studies that got the drug originally approved were for BPH, not baldness. As such, the dosage for BPH is 5 mg, versus 1 mg for baldness.
So, are we to believe that men in their 50's and 60's that likely have less robust sexual functional systems as compared to a 20-30 year old, somehow have more resilience to a dosage that is 5 times the amount given to a 20-30 year old? (BPH dosage is usually 5 mg and baldness is usually 1 mg). Let's don't forget that over 50% of men over 50 will experience some form of ED. What gives here?
I seek answers. If my facts are incorrect, have a field day -- I want to understand this issue.
"However, extensive examinations of various hormone levels and ratios, body fat comparisons, strength comparisons, and memory/recall tests comparisons showed that there were no significant differences across the 3 groups."
If you go through Propeciahelp you will find plenty of men with decreased hormone levels and memory recall issues. General medicine refers to men with testosterone levels below 231 ng/dl as having the condition 'low testosterone.' It seems convenient that Harvard didn't study PFS participants with 'low testosterone/androgen deficiency', therefore the outcome was always going to show that PFS participants did not have androgen deficiency. One of the symptoms of low testosterone is impaired memory so Harvard again dodged another issue by studying men with healthy testosterone levels above 433ng/dl. Either all PFS participants who applied to take part in the study had healthy hormone levels or Harvard chose not to include men with androgen deficiency.
According to this scale below the makers of nebido are saying men with testosterone above 346 ng/dl don't require testosterone substitution. It also shows that the normal range for testosterone starts at 433 ng/dl and continues to 1150 ng/dl. So Harvard studied PFS men with normal testosterone levels.
What was Harvard's objective? To determine whether these persistent symptoms after discontinuation of finasteride use are due to androgen deficiency, decreased peripheral androgen action, or persistent inhibition of steroid 5α-reductase (SRD5A) enzymes.
So again, how do you prove whether these persistent symptoms after discontinuation of Finasteride use are due to androgen deficiency when the majority or all of the participants in the study didn't have androgen deficiency in the first place.
I hope the Baylor and Italian studies show way more than the weak ass Harvard one did.
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