I've turned 40 a few days ago. In a nutshell, a few months ago my life was literally ruined - while I'm doing better now, it's left a pretty big scar and more drama to my life than I would care to have. But life happens as you often say and one has to roll with the punches. I guess it's best that I tell you about the main parts striving not to make this post overly long. My better half left me (though she's back now) though the cascade of events from the morning she left (quite unexpectedly, so yes it came as a devastating shock to me and I choose my words carefully here) to now, has caused tremendous upheaval with the brother and sister-in-law. Without going into any further details, as that would be way too long a post, I've been stabbed in the back by people I'd known and saw on a regularly basis for 16 years - I've never ever been that mad (seething anger would be more like it) in my whole life - they came and destroyed my life at a time where I could barely keep my head out of the water - perhaps some reading this post will relate to me through having experienced similar hardship. Keep in mind I've skipped a lot of details as it'd be tremendously time consuming both for you and for me. Moving to the positive part now : I've had low libido and moderate ED for 13 years now, with moderate improvements over the last few months (despite the ordeal). As a summary, I was diagnosed with ADHD 5 years ago, but I had an overnight stay at the hospital about two months ago - the next morning, I saw the same psychiatrist I saw 5 years ago - he removed his initial ADHD Dx, because I couldn't have completed 3 out of 4 years towards my BSc in nursing if I had an actual case of ADHD, especially if unmedicated. What's more, I've tried Adderall XR for a week and it made me worse. What I was found to have is OCPD and there's no doubt I have this big time ! This has caused me to get into trouble dealing with people - I'm a good person who's done some bad things. I've found meditation to be of significant help towards bringing my anxiety more manageable - years ago, I'd laugh at meditation, but I no longer do - one lives and learn. A few clinically related data : I've had MPB and elevated serum DHT - I'm pretty much addicted to internet porn and well fapped ~ twice daily for as long as I can recall. I've never been on either Finasteride nor Dutasteride - Last TT was 525 ng/dl, E2 was : 33 pg/ml, FT hasn't been done, but BAT was and came back slightly above mid-range. TSH has been consistently 2.0 or slightly above, but that alone can't explain a complete loss of sex drive. FT4 was done once and came back in the upper third of range - FT3 wasn't done because the lab my primary care practitioner does business with doesn't do FT3 if FT4 is within range. As far as cortisol goes, AM/PM serum cortisol has been just where it should be and salivary cortisol doesn't point to AF (though we know AF is about the command center and not the adrenals per se). I've found milk thistle to : significantly increase well-being and help with libido and ED to a moderate extent, which to me is pretty significant. Through researching this (Can provide the PMID if required) I've found sylimarin has been found to have anxiolytic action, so I may or may not derive benefits from milk thistle through this action. Now, the second I've experience even more significant benefits from is stinging nettle root extract ( Now Foods), though my last SHBG came back pretty normal as far as I know : SHBG : 25.3 (11.0 - 63.0) nmol/L Stinging nettle root has caused a significant increased in well-being, dramatically improvement in ED, moderate increase in libido, overall increase in energy and motivation to get things done. While on it, I feel less obsessive about things. I didn't expect to experience any benefits from it, given how normal my SHBG looks to be (unless I'm mistaken). IIRC is inhibits DHT from binding to the it's receptors in the prostate, but it doesn't actually lower systemic DHT. I've found this about stinging nettle, but don't know whether the following page actually discusses the benefits of the leaves over the root : http://www.mskcc.org/cancer-care/herb/nettle Because of the already normal SHBG and because of the way it seems to interact with DHT, I'm puzzled as to what could cause it for me to experience the above mentioned benefits. I thought about inflammation, which would make more sense to me, espcially since it only takes a few hours for it to kick in, leading me to think the MOA might not have to do with hormones. Clearly, stinging nettle root does cause my anxiety to decrease significantly, but I'd very much like to find out why it does so. There aren't many places on the web other than these forums where I could find an answer to this. Thank you.