I am 59 years old and have been following this forum for six months. Based on what I have learned here, I asked my PCP (internal medicine) to give me a testosterone test and an estrogen test (unfortunately I didn’t know enough to ask for an ultrasensitive assay), 8AM cortisol, and TSH, along with the customary blood tests during my birthday physical in November. I have been lifting for two years and lost 55 pounds during the first six months. I have put on 15 pounds since then while my body fat percentage has gone from “Oh My!” to 16.2. I lift 4 days and do cardio two days per week (treadmill at enough of an incline to get my heart rate up to age-adjusted maximum ~160bpm with an average of ~154 for the 35-45 minutes). I eat very clean with fish 2X/week, protein at about 1g/pound of body weight (170). First test: Hematology: All within range except MPV was low, 6.7 (8.2-13 fL) Chemistry: All within range. Fasting Lipid Profile: Cholesterol 184 mg/dL (50-200) Triglycerides 87 mg/dL (50-150) HDH Chol 44 mg/dL (40-60) LDL Chol, Direct 123 mg/dL (0-100) H *Near optimal/Above optimal* Quest Diagnostics: ACTH Plasma 14 pg/mL (7-50) Quest Diagnostics: 8 AM Cortisol 12.1 mcg/dL (4-22) Quest Diagnostics: Estradiol, Free, LC/MS/MS Estradiol, Free .21 pg/mL (< or = 0.45) Estradiol, % Free 2.08 H (1.25-1.85) Estradiol 10 (< or = 29) Quest Diagnostics: Testosterone, Free, BAT, Total, LC/MS/MS Testosterone, Total 197 L (250-1100 ng/dL) Testosterone, Free 32.8 L (46-224 pg/mL) Testosterone, Bioavailable 61.7 L (110-575 nmol/L) SBGH 23 (18-47) Albumin, Serum 4.1 (3.6-5.1) I was concerned about my LDL from the first test because of how much I exercise and how clean I eat. My PCP wanted to start slowly with T because he had a patient once (he doesn’t do much of this) whose LDL jumped 100 points when he first started T. He started with on a ridiculously low dose of Test-C (.5 cc of 200mg/ml Testosterone Cypionate/month). After 4 weeks I gave myself the second shot and 3 days later he ordered another Lipid profile (non-fasting). My LDL had increased to 170! To his credit, he didn’t pull me off the testosterone and actually increased my dosage to .5 cc every two weeks which I asked to administer at .25 weekly and he agreed. My Questions: Is it normal for LDL to temporarily increase when one first starts taking testosterone IM? Can high free Estradiol cause this increase? What the heck is going on?