This is my first post to this remarkable web site. It's almost like a secret club. I know the following topic was touched upon recently, but it didn't go in the direction that I was hoping. Therefore, I present it again. I am 62 and have been doing weekly intramuscular injections for 9 months under Dr Cryslers care. Awhile ago I listened to his April 22rd, 2009 lecture, http://progressive.uvault.com/pd1005/A4M091/WKS3/02Crisler/player.HTM and became aware, for the first time, that there is yet another possible route of entry for T into the body. I was aware of the standard 5 routes of entry: oral, IM, topical, pellets and sublingual. Each of these has some positives and also negatives. For me, the new route was suppositories. A woman asked Dr Crysler and Dr Mark Gordon about this approach in the question period after the lecture. Both Drs sounded positive in their replies about it. Now, I know that there is a percent of our group who feel: "There is no way I would ever stick anything up my butt." I can appreciate that feeling. I also know there is another percent who are willing to do whatever it takes. As for me, I would eat stir-fried dog crap if I knew it would help. From my current understanding, suppositories have the highest positives and lowest negatives of any of the 6 routes of entry. Positives: 1) Fast and low "bother" to administer. Similar to oral. 2) Clean to administer. Similar to oral, but topical not so much. Topical has its negatives in this area, rubbing off etc. 3) Allows for daily administration. Similar to oral, topical sublingual. The more I learn about the body, the more important it seems to get aligned with its desire for cycling, especially with daily cycling. As Dr Crysler said somewhere, weekly injections give an old-man T pattern. 4) Doesn't generate DHT. To me this is THE big negative with topical. I have had significant hair loss in the last 9 months with IM (though maybe its stabilized using Dr Crylers Magic Hair Formula). I just wouldn't want to take a chance with topical. There isn't much hair left up there. Dr Gordon said "there is no 5 alpha reductase problem" with suppositories (meaning no additional DHT generated at the point of absorption?). 5) Accurate dosing. Maybe similar to IM. It's in there and its not going any place (assuming you've worked out your elimination timing). Topical, who knows how much gets lost. 6) Dr Gordon said the amount of T needed is lower with suppositories, "one quarter to half the amount." He also said "it absorbs incredibly well." 7) Maybe use pure T, or T plus T cyp, or some other combination. Negatives: 1) Social prejudice about the entry location. To me, this is simply a non-issue. Work it into your daily routine. Pretend like you have hemroids. Get over it. 2) Timing with your bodies natural elimination cycle. Again to me, this is probably a non-issue. My body is very predictable. What about inserting it upon going to bed. Better yet, in the morning right after the first BM. You probably only need a couple hours for absorption. You could get a couple daily spikes. This idea is new and very appealing to me. Is my analysis above accurate? Other questions: Will the rectal mucosa tolerate a daily dose of T? If suppositories are so easy and good, why aren't guys using them. Social prejudice? Are the cells around the insertion point more prone to make DHT? Dr Crysler said that scrotal skin generated 50 times the DHT of regular skin. Maybe a special tool to get the suppository in there cleanly. How deep does it need to be inserted? Etc. I can only find one company making T suppositories, a German company named Funke(?). Not very common. I hope we can skip the teenage locker-room silliness and have a serious discussion about this.