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The Five-year Effects Of Testosterone Replacement Therapy On Lipid Profile And Glucose...

Discussion in 'Scientific Studies' started by pubmed: testosterone, Jan 18, 2019.


  1. The five-year effects of testosterone replacement therapy on lipid profile and glucose tolerance among hypogonadal men in Japan: a case control study.

    Aging Male. 2019 Jan 16;:1-6

    Authors: Kato Y, Shigehara K, Nakashima K, Iijima M, Kawagushi S, Nohara T, Izumi K, Kadono Y, Konaka H, Namiki M, Mizokami A

    Abstract
    OBJECTIVE: This study investigated the efficacy of 5-year testosterone replacement therapy (TRT) on lipid profile and glucose tolerance in Japanese hypogonadal men.
    METHODS: Fourteen patients, who received continuous TRT for 5 years, and 22 controls with 5-year observations were enrolled. The patients in the TRT group had received intramuscular injections of testosterone enanthate (250 mg) every month for 5 years. We collected the following data: blood pressure, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), total cholesterol, triglyceride (TG), high density lipoprotein-Chol values, and prostate specific antigen (PSA) level at baseline, 1-, 3-, and 5-years from initial intervention. These data were compared between the two groups.
    RESULTS: There were no statistically significant differences in any other baseline characteristic, excluding SBP, between the two groups. FBS was significantly improved at 3- and 5-year visits in the TRT group compared to the control group. Furthermore, the HbA1c level and TG value demonstrated a significant decrease at 1-, 3-, and 5-years in the TRT group. However, no significant difference in changes to PSA levels from baseline in both groups was observed.
    CONCLUSIONS: Five-year TRT could improve FBS, HbA1c, and TG levels among Japanese hypogonadal men with no significant increase in PSA.

    PMID: 30651019 [PubMed - as supplied by publisher]

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