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  1. #1
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    Default PT-141 (Bremelanotide) experience

    As promised, this is an account of my first experience with this peptide. I won't go into the details of the origin of this product as it is widely described on various websites. However, it is important to know that it is a derivative of the well publicised sun tan peptide Melanotan. There is a US patent on it. However, custom peptide laboratories can easily manufacture the product against its chemical formula. Consequently, it is available from labs all over the world, most of which are very coy about their identity.
    Prior to buying my first vial, I did extensive research on various laboratories and eventually found one in Europe that has hundreds of favourable reviews from users. There's no way to know how authentic those reviews may be but, on the basis of statistical chance, I decided to go ahead with the online purchase.
    The vial arrived on Friday, with no paperwork and no label on the vial - just a coloured seal. I e-mailed the supplier for reassurance and received a very articulate response with a reasonable explanation of the reasons for that procedure.
    I decided that I was prepared to take the risk so I continued with the process of diluting the dried crystals in the vial with sterile water and then filling and freezing (-19deg C) nine insulin syringes, leaving the one that I injected at 8pm last night.
    Within 30minutes, I was aware of a warm facial glow but could see no flushing in the mirror. That feeling went away within 10 minutes and I had no further side effects before bedtime around midnight.
    At 3.30am, I awoke with a raging erection so I got up and walked around for about 30 minutes and the erection gradually subsided. I took my blood pressure and was disturbed to find that it was 155/90. I went back to bed and had a somewhat disturbed few hours, being aware of frequent erections. I eventually woke up at 8am with a strong erection but decided to try to sleep on as I was feeling exhausted.
    I again woke at 9am with no erection and my wife and I did a bit of smooching to see if it would come back but without success. That was the end of the matter. I again took my BP and it was 134/80.
    So, my first experience with PT-141 has been a 'Wow!' followed by disappointment.
    There are another nine shots in the freezer, so I will have to try it again but I don't have great expectations. The logical first step is that the injection should take place at bedtime to allow for the window of opportunity to occur in the waking hours of the morning.
    Last edited by TopGeek; 07-10-2011 at 09:59 AM.

  2. #2
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    Default Re: PT-141 (Bremelanotide) experience

    Thanks for sharing.

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    Default Re: PT-141 (Bremelanotide) experience

    Great description and thanks for sharing.

    What is your usual Blood Pressure?

    Do you have a bio with more info on your ED workup?
    This would help others who might have similar conditions...

    Thanks.

    AG

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by AndroGeorge View Post
    What is your usual Blood Pressure?

    Do you have a bio with more info on your ED workup?
    My BP has been regularly 130/80 for years but has risen to 142/85 in the last few weeks. The only change in medication that I could think of is that I dropped fenofibrate and started 200mg Niacin per day.

    My ED history has been covered in my previous posts and my blood tests are in my profile. Briefly - 71 years old now, started Viagra in 1999, Cialis in 2000, developed eye probs in 2007 which were attributed to the Cialis. Without a PDE5 inhibitor, found that I had total ED. Tried Androgel which worked fine but I did not like the testicular atrophy it caused. The rest is here:

    http://www.allthingsmale.com/forum/s...-in-this-forum

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by TopGeek View Post
    My BP has been regularly 130/80 for years but has risen to 142/85 in the last few weeks. The only change in medication that I could think of is that I dropped fenofibrate and started 200mg Niacin per day.

    My ED history has been covered in my previous posts and my blood tests are in my profile. Briefly - 71 years old now, started Viagra in 1999, Cialis in 2000, developed eye probs in 2007 which were attributed to the Cialis. Without a PDE5 inhibitor, found that I had total ED. Tried Androgel which worked fine but I did not like the testicular atrophy it caused. The rest is here:

    http://www.allthingsmale.com/forum/s...-in-this-forum
    if androgel worked and you're worried about testicular atrophy you could try clomid along with your androgel, i mean if it works for ED then try some clomid, you may be one of the more fortunate ones who respond good to clomid and perhaps reap extra sexual benefits

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by cumkwakka View Post
    if androgel worked and you're worried about testicular atrophy you could try clomid along with your androgel, i mean if it works for ED then try some clomid, you may be one of the more fortunate ones who respond good to clomid and perhaps reap extra sexual benefits
    The ED specialist that I saw last year told me he would not prescribe Clomid because it also has a high risk of eye problems. It's also supposed to not work for men over about 45 -50 years of age. On the other hand, HCG could work but the combined private cost of Androgel and HCG would be very high, especially compared to PT-141.

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by TopGeek View Post
    The ED specialist that I saw last year told me he would not prescribe Clomid because it also has a high risk of eye problems. It's also supposed to not work for men over about 45 -50 years of age. On the other hand, HCG could work but the combined private cost of Androgel and HCG would be very high, especially compared to PT-141.
    Yes, I would stay away from Clomid and PDE5's due to already established vision problems..

    But you just reminded me that you have a low BAT.
    Raising it may help with erections on its own, but possibly combination BAT + (PT-141) and control of E2 may be better ticket to a happy wife.

    I do not remember your DHT levels.
    Usually only few people need (expensive) Androgel because of their low DHT.
    Most can happily get by using Testosterone enanthate, cypionae or Sustanon-250.
    Injectable testosterone and HCG are highly inexpensive when comparing to coast of Androgel.

    In the past you were leery about injections.
    But you are not a virgin now, after little experience with PT-141
    Just use 31Ga 5/16" long needles and you will not even know that you are injecting.
    First two months inject around nave 1"-3" off the navel.
    ...........
    Last edited by JanSz; 07-10-2011 at 04:58 PM.
    I am not a Dr, any opinion that I have is based on my own experience.
    Any changes in my regime are always discussed with and are approved by my doctor.

    Diabetes is not a disease. It is how mammals signal for the coming winter. You can cure it naturally.
    ...all legitimate rights have one thing in common: they are rights to action, not to rewards from other people."
    Failure is the spice that gives success its flavors………….If you don’t do the fear, you won’t get the courage.

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    Default Re: PT-141 (Bremelanotide) experience

    I must be suffering brain fog today JanSz.

    What is BAT?

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    Default Re: PT-141 (Bremelanotide) experience

    The one thing I guess the bremelanotide erection proves is that I don't have a blood-flow problem. It was also an erection the like of which I have not experienced for many years. Consequently, I think I could be quite happy with that, so long as I can get the timing right. Spontaneity is out of the window but ...
    Presumably the 'window of opportunity' varies from one person to another but to me it looks like 12 hours. That's disappointing because the rave notices about the product suggested that it could be effective for as long as two days.
    Last edited by TopGeek; 07-10-2011 at 05:15 PM.

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by TopGeek View Post
    I must be suffering brain fog today JanSz.

    What is BAT?
    BAT-BioAvailableTestosterone


    .........
    I am not a Dr, any opinion that I have is based on my own experience.
    Any changes in my regime are always discussed with and are approved by my doctor.

    Diabetes is not a disease. It is how mammals signal for the coming winter. You can cure it naturally.
    ...all legitimate rights have one thing in common: they are rights to action, not to rewards from other people."
    Failure is the spice that gives success its flavors………….If you don’t do the fear, you won’t get the courage.

  11. #11
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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by TopGeek View Post
    The one thing I guess the bremelanotide erection proves is that I don't have a blood-flow problem. It was also an erection the like of which I have not experienced for many years. Consequently, I think I could be quite happy with that, so long as I can get the timing right. Spontaneity is out of the window but ...
    Presumably the 'window of opportunity' varies from one person to another but to me it looks like 12 hours. That's disappointing because the rave notices about the product suggested that it could be effective for as long as two days.
    That was one of the kind erections. Follow ups may not be as strong but still usable.
    Just tell your girl to not waste time when the time comes.

    Good E2 levels are highly important in this context.

    ...
    I am not a Dr, any opinion that I have is based on my own experience.
    Any changes in my regime are always discussed with and are approved by my doctor.

    Diabetes is not a disease. It is how mammals signal for the coming winter. You can cure it naturally.
    ...all legitimate rights have one thing in common: they are rights to action, not to rewards from other people."
    Failure is the spice that gives success its flavors………….If you don’t do the fear, you won’t get the courage.

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by JanSz View Post
    That was one of the kind erections. Follow ups may not be as strong but still usable.
    Just tell your girl to not waste time when the time comes.

    Good E2 levels are highly important in this context.

    ...
    I'm still taking 50mg DHEA per day and 0.25mg Arimidex EOD.

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    Default Re: PT-141 (Bremelanotide) experience

    Topgeek, thanks for sharing your experience.

    I am wondering, why don't you try HCG monotherapy
    or testosterone with HCG? HCG would help the testicular
    shrinking and does not give eye problems as far as I know.

    Sharpman

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by JanSz View Post
    BAT-BioAvailableTestosterone


    .........
    Of course! Unfortunately, I do have rather high shbg so I have to either raise T or lower shbg in order to raise BAT. As we all know, it's not easy to lower shbg and supplementing T has undesirable side-effects.

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    Default Re: PT-141 (Bremelanotide) experience

    Quote Originally Posted by TopGeek View Post
    Of course! Unfortunately, I do have rather high shbg so I have to either raise T or lower shbg in order to raise BAT. As we all know, it's not easy to lower shbg and supplementing T has undesirable side-effects.
    I like good levels of BAT.

    You have high SHBG & CBG (Transcortin).
    Possibly some other binding proteins are out of their normal range.

    If you would arrange for high dose of testosterone your SHBG (and possibly Transcortin) would get down.
    We had couple guys doing it with this (predictable) results.
    One of those guys is Bryce720 who on top of other problems have hemachromatosis due to genetic problems.

    On one of the dr Gordon's presentations I noted that he is not a shy at all in raising testosterone when facing patient with high SHBG.
    Dr Gordon is on dr John's list of favorite doctors.

    Dr Vermulen's chart is handy to monitor theraphy.
    You normally want to get your FreeTestosterone into
    FreeT(250-300)
    range
    In this case, to put more pressure on SHBG, FreeT~400 may do better job.
    Dr Gordon went out up to FreeT~475 on the patient discussed on presentation I observed.
    ==============================================
    I imagine procedure for you:
    Testosterone Cypionate 200mg/mL

    T-shot=25units/day=50mg/day=350mg/week
    HCG-shot=400iu/EOD

    Mandatory, frequent monitoring of at least

    Hgb (phlebotomy when >(16.5-17.5)
    SHBG (goal ~20)
    E2, sensitive (goal ~20)
    Dihydrotestosterone
    5α-Androstane-3α, 17β-Diol Glucuronide, Serum

    If you can arrange there is more interesting tests that you may consider.



    ==============================================

    I am not a Dr, any opinion that I have is based on my own experience.
    Any changes in my regime are always discussed with and are approved by my doctor.

    Diabetes is not a disease. It is how mammals signal for the coming winter. You can cure it naturally.
    ...all legitimate rights have one thing in common: they are rights to action, not to rewards from other people."
    Failure is the spice that gives success its flavors………….If you don’t do the fear, you won’t get the courage.

 

 

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